Structural imaging in premanifest and manifest Huntington disease.
Handb Clin Neurol
; 144: 247-261, 2017.
Article
em En
| MEDLINE
| ID: mdl-28947121
ABSTRACT
Huntington disease (HD) neuropathology has a devastating effect on brain structure and consequently brain function; neuroimaging provides a means to assess these effects in gene carriers. In this chapter we first outline the unique utility of structural imaging in understanding HD and discuss some of the acquisition and analysis techniques currently available. We review the existing literature to summarize what we know so far about structural brain changes across the spectrum of disease from premanifest through to manifest disease. We then consider how these neuroimaging findings relate to patient function and nonimaging biomarkers, and can be used to predict disease onset. Finally we review the utility of imaging measures for assessment of treatment efficacy in clinical trials.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Encéfalo
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Doença de Huntington
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Neuroimagem
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article