Peroxisome proliferator-activated receptor gamma (PPARÎ³) regulates lactase expression and activity in the gut.

Fumery, Mathurin; Speca, Silvia; Langlois, Audrey; Davila, Anne-Marie; Dubuquoy, Caroline; Grauso, Marta; Martin Mena, Anthony; Figeac, Martin; Metzger, Daniel; Rousseaux, Christel; Colombel, Jean-Frederic; Dubuquoy, Laurent; Desreumaux, Pierre; Bertin, Benjamin

Fumery, Mathurin; Speca, Silvia; Langlois, Audrey; Davila, Anne-Marie; Dubuquoy, Caroline; Grauso, Marta; Martin Mena, Anthony; Figeac, Martin; Metzger, Daniel; Rousseaux, Christel; Colombel, Jean-Frederic; Dubuquoy, Laurent; Desreumaux, Pierre; Bertin, Benjamin.

Afiliação

Fumery M; U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, Lille, France.
Speca S; Inserm, U995, Lille, France.
Langlois A; Service d'Hépatogastroentérologie, Centre Hospitalier Universitaire d'Amiens Université de Picardie Jules Verne, Amiens, France.
Davila AM; U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, Lille, France.
Dubuquoy C; Inserm, U995, Lille, France.
Grauso M; U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, Lille, France.
Martin Mena A; Inserm, U995, Lille, France.
Figeac M; UMR0914, Institut National de la Recherche Agronomique/AgroParisTech, Université Paris-Saclay, Paris, France.
Metzger D; Intestinal Biotech Development, Lille, France.
Rousseaux C; UMR0914, Institut National de la Recherche Agronomique/AgroParisTech, Université Paris-Saclay, Paris, France.
Colombel JF; U995-LIRIC-Lille Inflammation Research International Center, Univ. Lille, Lille, France.
Dubuquoy L; Inserm, U995, Lille, France.
Desreumaux P; Functional and Structural Genomic Platform, Université de Lille, Lille, France.
Bertin B; Institut de Génétique et de Biologie Moléculaire et Cellulaire CNRS, UMR7104/INSERM U964/Université de Strasbourg Collège de France, Paris, France.

EMBO Mol Med ; 9(11): 1471-1481, 2017 11.

Article em En | MEDLINE | ID: mdl-28947679

Assuntos

Intestino Delgado/metabolismo; Lactase/metabolismo; PPAR gama/metabolismo; Compostos de Anilina/farmacologia; Compostos de Anilina/uso terapêutico; Animais; Células CACO-2; Imunoprecipitação da Cromatina; Dieta; Humanos; Lactase/genética; Lactose/metabolismo; Intolerância à Lactose/tratamento farmacológico; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microscopia de Fluorescência; Mutagênese Sítio-Dirigida; PPAR gama/agonistas; PPAR gama/genética; Fenilpropionatos/farmacologia; Fenilpropionatos/uso terapêutico; Regiões Promotoras Genéticas; Ratos; Ratos Sprague-Dawley; Transcrição Gênica/efeitos dos fármacos

Palavras-chave

PPARgamma; hypolactasia; intestinal epithelial cells; lactase; lactose intolerance

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lactase / PPAR gama / Intestino Delgado Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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