[Expression of Wnt and integrin pathways in colorectal laterally spreading tumors and their correlation with endoscopic subtypes].
Nan Fang Yi Ke Da Xue Xue Bao
; 37(9): 1234-1241, 2017 Sep 20.
Article
em Zh
| MEDLINE
| ID: mdl-28951368
ABSTRACT
OBJECTIVE:
To investigate the expression of Wnt and integrin pathways in colorectal laterally spreading tumors (LSTs) and their correlation with the different endoscopic subtypes of LSTs to better understand the special growth mechanism of LSTs.METHODS:
Fifty-two patients with colorectal LSTs were randomly selected from the cases diagnosed between January 1, 2010 and June 10, 2015 in our hospital, including 37 of nodular mixed type (LST-G-M), 60 of homogeneous type (LST-G-H), 5 of flat elevated type (LST-NG-FE), and 4 of pseudodepressed type (LST-NG-PD). The expression of ß-catenin, phospho- GSK-3ß, paxillin and ILK in 52 colorectal LSTs and 15 protruded adenomas (PAs) were investigated by immunohistochemical staining. The correlation of ß-catenin, phospho-GSK-3ß, paxillin and ILK expressions among the endoscopic subtypes of LSTs were analyzed.RESULTS:
ß-catenin expression was significantly higher in LSTs than in Pas (P<0.05). ß-catenin, phospho-GSK-3ß, paxillin and ILK expressions were significantly higher in LST-NG-PD than in Pas (P<0.05). The expressions of ß-catenin, phospho-GSK-3ß and ILK expression were significantly correlated in LSTs (P<0.05) but not in PAs (P>0.05).CONCLUSION:
The macroscopic feature of LST-NG-PD may result from a special mechanism of development distinct from other endoscopic subtypes; ILK may play a role in regulating Wnt signaling in LSTs.
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Base de dados:
MEDLINE
Idioma:
Zh
Ano de publicação:
2017
Tipo de documento:
Article