Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinaseâ2 (TSSK2).

Hawkinson, Jon E; Sinville, Rondedrick; Mudaliar, Deepti; Shetty, Jagathpala; Ward, Timothy; Herr, John C; Georg, Gunda I

Potent Pyrimidine and Pyrrolopyrimidine Inhibitors of Testis-Specific Serine/Threonine Kinaseâ2 (TSSK2).

Hawkinson, Jon E; Sinville, Rondedrick; Mudaliar, Deepti; Shetty, Jagathpala; Ward, Timothy; Herr, John C; Georg, Gunda I.

Afiliação

Hawkinson JE; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55414, USA.
Sinville R; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55414, USA.
Mudaliar D; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55414, USA.
Shetty J; Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, VA, 22908, USA.
Ward T; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55414, USA.
Herr JC; Department of Cell Biology, Center for Research in Contraceptive and Reproductive Health, University of Virginia, Charlottesville, VA, 22908, USA.
Georg GI; Institute for Therapeutics Discovery and Development, Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, MN, 55414, USA.

ChemMedChem ; 12(22): 1857-1865, 2017 11 22.

Article em En | MEDLINE | ID: mdl-28952188

Assuntos

Inibidores de Proteínas Quinases/farmacologia; Proteínas Serina-Treonina Quinases/antagonistas & inibidores; Pirimidinas/farmacologia; Pirróis/farmacologia; Relação Dose-Resposta a Droga; Ensaios de Triagem em Larga Escala; Humanos; Estrutura Molecular; Inibidores de Proteínas Quinases/síntese química; Inibidores de Proteínas Quinases/química; Proteínas Serina-Treonina Quinases/isolamento & purificação; Proteínas Serina-Treonina Quinases/metabolismo; Pirimidinas/síntese química; Pirimidinas/química; Pirróis/síntese química; Pirróis/química; Relação Estrutura-Atividade

Palavras-chave

high-throughput screening; kinase inhibitors; male contraception; structure-activity relationships; testis-specific serine/threonine kinase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Pirróis / Proteínas Serina-Treonina Quinases / Inibidores de Proteínas Quinases Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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