Copper promoted N-alkylation of sulfoximines with alkylboronic acid under mild conditions.
Org Biomol Chem
; 15(40): 8493-8498, 2017 Oct 18.
Article
em En
| MEDLINE
| ID: mdl-28952646
ABSTRACT
The copper meditated N-methylation of sulfoximines using methylboronic acid is reported. The reactions provide excellent yields in a short span of time under mild conditions. The optimized conditions were also found to be suitable for the N-alkylation of sulfoximine with different alkylboronic acids. In addition, N-methylation and cyclopropylation of the bioactive l-methionine sulfoximine derivative was demonstrated under standard reaction conditions.
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MEDLINE
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article