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Design and Synthesis of Ligand Efficient Dual Inhibitors of Janus Kinase (JAK) and Histone Deacetylase (HDAC) Based on Ruxolitinib and Vorinostat.
Yao, Lianbin; Mustafa, Nurulhuda; Tan, Eng Chong; Poulsen, Anders; Singh, Prachi; Duong-Thi, Minh-Dao; Lee, Jeannie X T; Ramanujulu, Pondy Murugappan; Chng, Wee Joo; Yen, Jeffrey J Y; Ohlson, Sten; Dymock, Brian W.
Afiliação
  • Yao L; Department of Pharmacy, National University of Singapore , 18 Science Drive 4, 117543, Singapore.
  • Mustafa N; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore , 1E Kent Ridge Road, NUHS Tower Block Level 10, 117549, Singapore.
  • Tan EC; Institute of Biomedical Sciences, Academia Sinica , Taipei 115, Taiwan.
  • Poulsen A; Taiwan International Graduate Program in Molecular Medicine, National Yang-Ming University and Academia Sinica , Taipei, 115, Taiwan.
  • Singh P; Experimental Therapeutics Centre , 31 Biopolis Way, 03-01 Nanos, 138669, Singapore.
  • Duong-Thi MD; Department of Chemistry, National University of Singapore , 3 Science Drive 3, 117543, Singapore.
  • Lee JXT; School of Biological Sciences, Nanyang Technological University (NTU) , 637551, Singapore.
  • Ramanujulu PM; School of Biological Sciences, Nanyang Technological University (NTU) , 637551, Singapore.
  • Chng WJ; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore , 1E Kent Ridge Road, NUHS Tower Block Level 10, 117549, Singapore.
  • Yen JJY; Department of Pharmacy, National University of Singapore , 18 Science Drive 4, 117543, Singapore.
  • Ohlson S; Centre for Life Sciences Level 5, Life Sciences Institute, National University of Singapore , 28 Medical Drive, 117456, Singapore.
  • Dymock BW; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore , 1E Kent Ridge Road, NUHS Tower Block Level 10, 117549, Singapore.
J Med Chem ; 60(20): 8336-8357, 2017 10 26.
Article em En | MEDLINE | ID: mdl-28953386
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Inibidores de Proteínas Quinases / Janus Quinase 1 / Janus Quinase 2 / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirazóis / Inibidores de Proteínas Quinases / Janus Quinase 1 / Janus Quinase 2 / Inibidores de Histona Desacetilases / Ácidos Hidroxâmicos Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article