Acute flaccid paralysis in South African children: Causes, respiratory complications and neurological outcome.
J Paediatr Child Health
; 54(3): 247-253, 2018 Mar.
Article
em En
| MEDLINE
| ID: mdl-28960591
ABSTRACT
AIM:
To describe the causes, clinical presentation and neurological outcome of acute flaccid paralysis in children.METHODS:
A retrospective study in a tertiary paediatric hospital in South Africa. Data on clinical presentation, respiratory complications and long-term neurological outcomes of children presenting with acute flaccid paralysis were collected. Logistic regression analysis was applied to determine predictors for the need of mechanical ventilation.RESULTS:
The study included 119 patients, 99 of whom had Guillain-Barré syndrome (GBS); 47 patients (39.5%) required mechanical ventilation. Backward logistic regression analysis revealed that bulbar dysfunction (P < 0.001), autonomic dysfunction (P = 0.003) and upper limb paralysis (P = 0.038) significantly predicted the need for mechanical ventilation. EuroQol-5D scores of self-care problems and usual activities after discharge significantly declined over time.CONCLUSIONS:
In this large series from Africa, GBS was the main cause of acute flaccid paralysis in children and was associated with significant morbidity. Other causes of acute flaccid paralysis mimicking GBS were not uncommon and should be excluded in this setting.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paralisia
/
Respiração Artificial
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Síndrome de Guillain-Barré
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Hipotonia Muscular
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
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Female
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Humans
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Infant
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Male
País como assunto:
Africa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article