Fusing Carborane Carboxylic Acids with Alkynes: 3D Analogues of Isocoumarins via Regioselective B-H Activation.
Chemistry
; 24(3): 551-555, 2018 Jan 12.
Article
em En
| MEDLINE
| ID: mdl-28961328
ABSTRACT
An iridium-catalyzed alkenylation/annulation sequence between monocarba-closo-dodecaborate carboxylic acids and diarylacetylenes is reported. Regioselective activation of the B2 position, followed by B-C bond formation and ring closure, affords 3D bora-analogues of isocoumarins. The reaction tolerates a variety of functional groups on the aromatic rings and can be extended to B12-substituted derivatives. Furthermore, subsequent alkenylation of the B4 vertex has been achieved in high yields.
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MEDLINE
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En
Ano de publicação:
2018
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Article