Pharmacogenetic Analysis of the UK MRC (Medical Research Council) MAGIC Trial: Association of Polymorphisms with Toxicity and Survival in Patients Treated with Perioperative Epirubicin, Cisplatin, and 5-fluorouracil (ECF) Chemotherapy.

Smyth, Elizabeth; Zhang, Shenli; Cunningham, David; Wotherspoon, Andrew; Soong, Richie; Peckitt, Clare; Valeri, Nicola; Fassan, Matteo; Rugge, Massimo; Okines, Alicia; Allum, William; Stenning, Sally; Nankivell, Matthew; Langley, Ruth; Tan, Patrick

Smyth, Elizabeth; Zhang, Shenli; Cunningham, David; Wotherspoon, Andrew; Soong, Richie; Peckitt, Clare; Valeri, Nicola; Fassan, Matteo; Rugge, Massimo; Okines, Alicia; Allum, William; Stenning, Sally; Nankivell, Matthew; Langley, Ruth; Tan, Patrick.

Afiliação

Smyth E; Department of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom.
Zhang S; Cancer and Stem Cell Biology Program, Duke-NUS Medical School, Singapore, Singapore.
Cunningham D; Department of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom. david.cunningham@rmh.nhs.uk.
Wotherspoon A; Department of Pathology, Royal Marsden Hospital, London & Sutton, United Kingdom.
Soong R; Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore.
Peckitt C; Department of Clinical Research and Development, Royal Marsden Hospital, London & Sutton, United Kingdom.
Valeri N; Department of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom.
Fassan M; Department of Molecular Pathology, The Institute of Cancer Research London & Sutton, United Kingdom.
Rugge M; Department of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Okines A; Department of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Allum W; Department of Gastrointestinal Oncology and Lymphoma, Royal Marsden Hospital, London & Sutton, United Kingdom.
Stenning S; Department of Medicine, Surgical Pathology & Cytopathology Unit, University of Padua, Padua, Italy.
Nankivell M; Department of Surgery, Royal Marsden Hospital, London & Sutton, United Kingdom.
Langley R; Department of Surgery, Royal Marsden Hospital, London & Sutton, United Kingdom.
Tan P; Medical Research Council Clinical Trials Unit at UCL, London, United Kingdom.

Clin Cancer Res ; 23(24): 7543-7549, 2017 Dec 15.

Article em En | MEDLINE | ID: mdl-28972045

Assuntos

Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/genética; Neoplasias Esofágicas/tratamento farmacológico; Neoplasias Gástricas/tratamento farmacológico; Timidilato Sintase/genética; Adulto; Idoso; Cisplatino/administração & dosagem; Intervalo Livre de Doença; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/classificação; Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/patologia; Epirubicina/administração & dosagem; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/patologia; Neoplasias Esofágicas/cirurgia; Feminino; Fluoruracila/administração & dosagem; Estudos de Associação Genética; Genótipo; Mutação em Linhagem Germinativa/genética; Humanos; Masculino; Pessoa de Meia-Idade; Proteínas de Neoplasias/genética; Período Perioperatório; Polimorfismo de Nucleotídeo Único/genética; Neoplasias Gástricas/genética; Neoplasias Gástricas/patologia; Neoplasias Gástricas/cirurgia; Reino Unido

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / Timidilato Sintase / Neoplasias Esofágicas / Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos Tipo de estudo: Clinical_trials / Risk_factors_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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