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A conserved degron containing an amphipathic helix regulates the cholesterol-mediated turnover of human squalene monooxygenase, a rate-limiting enzyme in cholesterol synthesis.
Chua, Ngee Kiat; Howe, Vicky; Jatana, Nidhi; Thukral, Lipi; Brown, Andrew J.
Afiliação
  • Chua NK; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
  • Howe V; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia.
  • Jatana N; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, Mathura Road, Sukhdev Vihar, New Delhi 110 020, India.
  • Thukral L; Council of Scientific and Industrial Research-Institute of Genomics and Integrative Biology, Mathura Road, Sukhdev Vihar, New Delhi 110 020, India.
  • Brown AJ; School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, New South Wales 2052, Australia. Electronic address: aj.brown@unsw.edu.au.
J Biol Chem ; 292(49): 19959-19973, 2017 12 08.
Article em En | MEDLINE | ID: mdl-28972164
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colesterol / Sequência Conservada / Complexo de Endopeptidases do Proteassoma / Esqualeno Mono-Oxigenase / Proteólise Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Colesterol / Sequência Conservada / Complexo de Endopeptidases do Proteassoma / Esqualeno Mono-Oxigenase / Proteólise Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article