An Iron-Rich Diet Decreases the Mycobacterial Burden and Correlates With Hepcidin Upregulation, Lower Levels of Proinflammatory Mediators, and Increased T-Cell Recruitment in a Model of Mycobacterium bovis Bacille Calmette-Guerin Infection.

Agoro, Rafiou; Benmerzoug, Sulayman; Rose, Stéphanie; Bouyer, Mélanie; Gozzelino, Raffaella; Garcia, Irene; Ryffel, Bernhard; Quesniaux, Valerie F J; Mura, Catherine

Agoro, Rafiou; Benmerzoug, Sulayman; Rose, Stéphanie; Bouyer, Mélanie; Gozzelino, Raffaella; Garcia, Irene; Ryffel, Bernhard; Quesniaux, Valerie F J; Mura, Catherine.

Afiliação

Agoro R; Experimental and Molecular Immunology and Neurogenetics (INEM), Mixed Research Unit UMR7355, National Center for Scientific Research.
Benmerzoug S; University of Orléans, Orléans, France.
Rose S; Experimental and Molecular Immunology and Neurogenetics (INEM), Mixed Research Unit UMR7355, National Center for Scientific Research.
Bouyer M; University of Orléans, Orléans, France.
Gozzelino R; Experimental and Molecular Immunology and Neurogenetics (INEM), Mixed Research Unit UMR7355, National Center for Scientific Research.
Garcia I; University of Orléans, Orléans, France.
Ryffel B; Experimental and Molecular Immunology and Neurogenetics (INEM), Mixed Research Unit UMR7355, National Center for Scientific Research.
Quesniaux VFJ; University of Orléans, Orléans, France.
Mura C; Inflammation and Neurodegeneration Laboratory, Chronic Diseases Research Centre/NOVA Medical School, Lisbon, Portugal.

J Infect Dis ; 216(7): 907-918, 2017 10 17.

Article em En | MEDLINE | ID: mdl-28973651

Assuntos

Citocinas/metabolismo; Hepcidinas/metabolismo; Ferro da Dieta/farmacologia; Mycobacterium bovis/imunologia; Linfócitos T/fisiologia; Tuberculose/microbiologia; Animais; Citocinas/genética; Hepcidinas/genética; Ferro/metabolismo; Fígado/metabolismo; Fígado/microbiologia; Pulmão/metabolismo; Pulmão/microbiologia; Camundongos; Tuberculose/imunologia; Regulação para Cima

Palavras-chave

Mycobacterium bovis BCG infection; hepcidin; inflammation; iron

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose / Linfócitos T / Citocinas / Ferro da Dieta / Hepcidinas / Mycobacterium bovis Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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