Retinoblastoma: Magnetic Isotope Effects Might Make a Difference in the Current Anti-Cancer Research Strategy.
Acta Medica (Hradec Kralove)
; 60(2): 93-96, 2017.
Article
em En
| MEDLINE
| ID: mdl-28976878
ABSTRACT
Human retinoblastoma cells were proven to possess some very unusual DNApolß species. Being 23.5 kDa monomers, which itself is not common for the DNApolß superfamily members, these chromatin associated proteins manifests most of the DNApolß-specifc functional peculiarities making them legitimate targets for DNA repair cytostatic inhibitors. Particularly, these tumor specific enzymes were found to be very sensitive to 25Mg2+-, 43Ca2+- and 67Zn2+-promoted magnetic isotope effects (MIE) caused a marked DNA sequence growth limitation as well as a formation of the size-invalid, i.e. too short in length, DNA fragments, totally inappropriate for the DNA repair purpose. This MIE-DNApolß match may serve a starting point for further move towards the paramagnetic path in current developments of anti-cancer strategies.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
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Reparo do DNA
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Fenômenos Magnéticos
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article