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Intramuscular triglyceride synthesis: importance in muscle lipid partitioning in humans.
Bergman, Bryan C; Perreault, Leigh; Strauss, Allison; Bacon, Samantha; Kerege, Anna; Harrison, Kathleen; Brozinick, Joseph T; Hunerdosse, Devon M; Playdon, Mary C; Holmes, William; Bui, Hai Hoang; Sanders, Phil; Siddall, Parker; Wei, Tao; Thomas, Melissa K; Kuo, Ming Shang; Eckel, Robert H.
Afiliação
  • Bergman BC; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Perreault L; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Strauss A; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Bacon S; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Kerege A; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Harrison K; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Brozinick JT; Eli Lilly, Indianapolis, Indiana.
  • Hunerdosse DM; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Playdon MC; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
  • Holmes W; Kinemed, Emeryville, California.
  • Bui HH; Eli Lilly, Indianapolis, Indiana.
  • Sanders P; Eli Lilly, Indianapolis, Indiana.
  • Siddall P; Eli Lilly, Indianapolis, Indiana.
  • Wei T; Eli Lilly, Indianapolis, Indiana.
  • Thomas MK; Eli Lilly, Indianapolis, Indiana.
  • Kuo MS; Eli Lilly, Indianapolis, Indiana.
  • Eckel RH; University of Colorado Anschutz Medical Campus , Aurora, Colorado.
Am J Physiol Endocrinol Metab ; 314(2): E152-E164, 2018 02 01.
Article em En | MEDLINE | ID: mdl-28978544
ABSTRACT
Intramuscular triglyceride (IMTG) concentration is elevated in insulin-resistant individuals and was once thought to promote insulin resistance. However, endurance-trained athletes have equivalent concentration of IMTG compared with individuals with type 2 diabetes, and have very low risk of diabetes, termed the "athlete's paradox." We now know that IMTG synthesis is positively related to insulin sensitivity, but the exact mechanisms for this are unclear. To understand the relationship between IMTG synthesis and insulin sensitivity, we measured IMTG synthesis in obese control subjects, endurance-trained athletes, and individuals with type 2 diabetes during rest, exercise, and recovery. IMTG synthesis rates were positively related to insulin sensitivity, cytosolic accumulation of DAG, and decreased accumulation of C180 ceramide and glucosylceramide. Greater rates of IMTG synthesis in athletes were not explained by alterations in FFA concentration, DGAT1 mRNA expression, or protein content. IMTG synthesis during exercise in Ob and T2D indicate utilization as a fuel despite unchanged content, whereas IMTG concentration decreased during exercise in athletes. mRNA expression for genes involved in lipid desaturation and IMTG synthesis were increased after exercise and recovery. Further, in a subset of individuals, exercise decreased cytosolic and membrane di-saturated DAG content, which may help explain insulin sensitization after acute exercise. These data suggest IMTG synthesis rates may influence insulin sensitivity by altering intracellular lipid localization, and decreasing specific ceramide species that promote insulin resistance.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Exercício Físico / Músculo Esquelético / Lipogênese Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triglicerídeos / Exercício Físico / Músculo Esquelético / Lipogênese Tipo de estudo: Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article