The interaction between vitamin D receptor polymorphisms and sun exposure around time of diagnosis influences melanoma survival.
Pigment Cell Melanoma Res
; 31(2): 287-296, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-28990310
ABSTRACT
Evidence on the relationship between the vitamin D pathway and outcomes in melanoma is growing, although it is not always clear. We investigated the impact of measured levels of sun exposure at diagnosis on associations of vitamin D receptor gene (VDR) polymorphisms and melanoma death in 3336 incident primary melanoma cases. Interactions between six SNPs and a common 3'-end haplotype were significant (p < .05). These SNPs, and a haplotype, had a statistically significant association with survival among subjects exposed to high UVB in multivariable regression models and exerted their effect in the opposite direction among those with low UVB. SNPs rs1544410/BsmI and rs731236/TaqI remained significant after adjustment for multiple testing. These results suggest that the association between VDR and melanoma-specific survival is modified by sun exposure around diagnosis, and require validation in an independent study. Whether the observed effects are dependent or independent of vitamin D activation remains to be determined.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Luz Solar
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Receptores de Calcitriol
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Predisposição Genética para Doença
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Polimorfismo de Nucleotídeo Único
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Melanoma
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article