A copper-catalyzed tandem reaction for the construction of coumarin fused 9H-pyrrolo[1,2-a]indoles.
Org Biomol Chem
; 15(41): 8729-8737, 2017 Oct 25.
Article
em En
| MEDLINE
| ID: mdl-28990624
ABSTRACT
An efficient copper-catalyzed Friedel-Crafts alkylation/cyclization/isomerization sequence of 3-arylcarbonyl coumarins and 3-methyl indole was developed to afford a wide range of functionalized coumarin fused 9H-pyrrolo[1,2-a]indoles, which feature a 6-6-5-5-6 pentacyclic core, in 34-99% yields. Moreover, gram-scale experiment and chemical transformations were conducted to demonstrate the synthetic value of this protocol.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cobre
/
Cumarínicos
/
Indóis
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article