Zika virus disease-associated Guillain-Barré syndrome-Barranquilla, Colombia 2015-2016.
J Neurol Sci
; 381: 272-277, 2017 Oct 15.
Article
em En
| MEDLINE
| ID: mdl-28991697
ABSTRACT
BACKGROUND:
An outbreak of Guillain-Barré syndrome (GBS), a disorder characterized by acute, symmetric limb weakness with decreased or absent deep-tendon reflexes, was reported in Barranquilla, Colombia, after the introduction of Zika virus in 2015. We reviewed clinical data for GBS cases in Barranquilla and performed a case-control investigation to assess the association of suspect and probable Zika virus disease with GBS.METHODS:
We used the Brighton Collaboration Criteria to confirm reported GBS patients in Barranquilla during October 2015-April 2016. In April 2016, two neighborhood and age range-matched controls were selected for each confirmed GBS case-patient. We obtained demographics and antecedent symptoms in the 2-month period before GBS onset for case-patients and the same period for controls. Sera were collected for Zika virus antibody testing. Suspected Zika virus disease was defined as a history of rash and ≥2 other Zika-related symptoms (fever, arthralgia, myalgia, or conjunctivitis). Probable Zika virus disease was defined as suspected Zika virus disease with laboratory evidence of a recent Zika virus or flavivirus infection. Conditional logistic regression adjusted for sex and race/ethnicity was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs).RESULTS:
We confirmed 47 GBS cases. Incidence increased with age (10-fold higher in those ≥60years versus those <20years). We interviewed 40 case-patients and 79 controls. There was no significant difference in laboratory evidence of recent Zika virus or flavivirus infection between case-patients and controls (OR 2.2; 95% CI 0.9-5.1). GBS was associated with having suspected (OR 3.0, 95% CI 1.1-8.6) or probable Zika virus disease (OR 4.6, CI 1.1-19.0).CONCLUSIONS:
Older individuals and those with suspected and probable Zika virus disease had higher odds of developing GBS. KEY POINTS We confirmed a Guillain-Barré syndrome (GBS) outbreak in Barranquilla, Colombia, during October 2015-April 2016. A case-control investigation using neighborhood controls showed an association of suspected and probable Zika virus disease with GBS.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Guillain-Barré
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Infecção por Zika virus
Tipo de estudo:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Child
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Female
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Humans
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Male
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Middle aged
País como assunto:
America do sul
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Colombia
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article