Radioprotective effect of lycopene on the gastrointestinal tract after high-dose radioiodine administration in rat models.
Nucl Med Commun
; 38(12): 1041-1046, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29023335
ABSTRACT
PURPOSE:
The aim of this study was to evaluate the effect of lycopene against radioactive iodine (RAI)-related gastrointestinal tract acute damage in a rat model as a novel radioprotective agent. MATERIALS ANDMETHODS:
Twenty Wistar albino rats were divided into two equal groups group 1 was administered only RAI and group 2 was administered RAI and lycopene. All rats were killed 24 h after the last administration of the agents and the gastrointestinal tract organs were removed surgically for histopathological examination.RESULT:
The presence of lamina propria edema in the duodenum (P=0.003) and ileum (P=0.02), ulcer in the duodenum (P=0.033), mucosal erosion in the stomach (P=0.001), mucosal degeneration in stomach (P=0.02) and colon (P=0.02), necrosis in all tissues (P value for stomach=0.005, duodenum=0.001, ileum=0.001, colon=0.001), inflammation in those tissues (P value for; stomach=0.003, duodenum=0.02, ileum=0.011, colon=0.033), and fibrosis in those tissues (P value for; stomach=0.02, duodenum=0.003, ileum=0.003, colon=0.001) were statistically less frequently observed in the lycopene group compared with the RAI group.CONCLUSION:
As a first study assessing the protective effect of lycopene on gastrointestinal tract organs in a rat model after RAI, these preliminary basic research findings suggest that lycopene appears to exert radioprotective effects against RAI-induced acute gastrointestinal tract damage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Protetores contra Radiação
/
Carotenoides
/
Trato Gastrointestinal
/
Radioisótopos do Iodo
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article