Neuro-Coagulopathy: Blood Coagulation Factors in Central Nervous System Diseases.
Int J Mol Sci
; 18(10)2017 Oct 12.
Article
em En
| MEDLINE
| ID: mdl-29023416
ABSTRACT
Blood coagulation factors and other proteins, with modulatory effects or modulated by the coagulation cascade have been reported to affect the pathophysiology of the central nervous system (CNS). The protease-activated receptors (PARs) pathway can be considered the central hub of this regulatory network, mainly through thrombin or activated protein C (aPC). These proteins, in fact, showed peculiar properties, being able to interfere with synaptic homeostasis other than coagulation itself. These specific functions modulate neuronal networks, acting both on resident (neurons, astrocytes, and microglia) as well as circulating immune system cells and the extracellular matrix. The pleiotropy of these effects is produced through different receptors, expressed in various cell types, in a dose- and time-dependent pattern. We reviewed how these pathways may be involved in neurodegenerative diseases (amyotrophic lateral sclerosis, Alzheimer's and Parkinson's diseases), multiple sclerosis, ischemic stroke and post-ischemic epilepsy, CNS cancer, addiction, and mental health. These data open up a new path for the potential therapeutic use of the agonist/antagonist of these proteins in the management of several central nervous system diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Coagulação Sanguínea
/
Fatores de Coagulação Sanguínea
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Doenças do Sistema Nervoso Central
Tipo de estudo:
Diagnostic_studies
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Etiology_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article