Network propagation in the cytoscape cyberinfrastructure.
PLoS Comput Biol
; 13(10): e1005598, 2017 Oct.
Article
em En
| MEDLINE
| ID: mdl-29023449
ABSTRACT
Network propagation is an important and widely used algorithm in systems biology, with applications in protein function prediction, disease gene prioritization, and patient stratification. However, up to this point it has required significant expertise to run. Here we extend the popular network analysis program Cytoscape to perform network propagation as an integrated function. Such integration greatly increases the access to network propagation by putting it in the hands of biologists and linking it to the many other types of network analysis and visualization available through Cytoscape. We demonstrate the power and utility of the algorithm by identifying mutations conferring resistance to Vemurafenib.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Software
/
Biologia de Sistemas
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article