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A large scale hearing loss screen reveals an extensive unexplored genetic landscape for auditory dysfunction.
Bowl, Michael R; Simon, Michelle M; Ingham, Neil J; Greenaway, Simon; Santos, Luis; Cater, Heather; Taylor, Sarah; Mason, Jeremy; Kurbatova, Natalja; Pearson, Selina; Bower, Lynette R; Clary, Dave A; Meziane, Hamid; Reilly, Patrick; Minowa, Osamu; Kelsey, Lois; Tocchini-Valentini, Glauco P; Gao, Xiang; Bradley, Allan; Skarnes, William C; Moore, Mark; Beaudet, Arthur L; Justice, Monica J; Seavitt, John; Dickinson, Mary E; Wurst, Wolfgang; de Angelis, Martin Hrabe; Herault, Yann; Wakana, Shigeharu; Nutter, Lauryl M J; Flenniken, Ann M; McKerlie, Colin; Murray, Stephen A; Svenson, Karen L; Braun, Robert E; West, David B; Lloyd, K C Kent; Adams, David J; White, Jacqui; Karp, Natasha; Flicek, Paul; Smedley, Damian; Meehan, Terrence F; Parkinson, Helen E; Teboul, Lydia M; Wells, Sara; Steel, Karen P; Mallon, Ann-Marie; Brown, Steve D M.
Afiliação
  • Bowl MR; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Simon MM; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Ingham NJ; King's College London, London, SE1 1UL, UK.
  • Greenaway S; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Santos L; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Cater H; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Taylor S; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Mason J; Medical Research Council Harwell Institute (Mammalian Genetics Unit and Mary Lyon Centre), Harwell, Oxfordshire, OX11 0RD, UK.
  • Kurbatova N; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
  • Pearson S; European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1 SD, UK.
  • Bower LR; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Clary DA; Mouse Biology Program, University of California, Davis, California, 95618, USA.
  • Meziane H; Mouse Biology Program, University of California, Davis, California, 95618, USA.
  • Reilly P; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), 1 rue Laurent Fries, Illkirch-Graffenstaden, F-67404, France.
  • Minowa O; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), 1 rue Laurent Fries, Illkirch-Graffenstaden, F-67404, France.
  • Kelsey L; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
  • Tocchini-Valentini GP; The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.
  • Gao X; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
  • Skarnes WC; Monterotondo Mouse Clinic, Italian National Research Council (CNR), Institute of Cell Biology and Neurobiology, I-00015, Monterotondo Scalo, Italy.
  • Moore M; SKL of Pharmaceutical Biotechnology and Model Animal Research Center, Collaborative Innovation Center for Genetics and Development, Nanjing Biomedical Research Institute, Nanjing University, 210061, Nanjing, China.
  • Beaudet AL; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Justice MJ; The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SA, UK.
  • Seavitt J; IMPC, San Anselmo, California, 94960, USA.
  • Dickinson ME; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
  • Wurst W; The Centre for Phenogenomics, Toronto, Ontario, Canada, M5T 3H7.
  • de Angelis MH; The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.
  • Herault Y; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
  • Wakana S; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
  • Nutter LMJ; Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA.
  • Flenniken AM; Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, 77030, USA.
  • McKerlie C; Institute of Developmental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.
  • Murray SA; German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Ingolstaedter Landstrasse 1, 85764, Neuherberg, Germany.
  • Svenson KL; CELPHEDIA, PHENOMIN, Institut Clinique de la Souris (ICS), 1 rue Laurent Fries, Illkirch-Graffenstaden, F-67404, France.
  • Braun RE; Institut de Génétique et de Biologie Moléculaire et Cellulaire (IGBMC), Université de Strasbourg, 67404, Illkirch, France.
  • West DB; Centre National de la Recherche Scientifique, UMR7104, 67404, Illkirch, France.
  • Lloyd KCK; Institut National de la Santé et de la Recherche Médicale, U964, 67404, Illkirch, France.
  • Adams DJ; RIKEN BioResource Center, Tsukuba, Ibaraki, 305-0074, Japan.
  • White J; The Centre for Phenogenomics, Toronto, Ontario, Canada, M5T 3H7.
  • Karp N; The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.
  • Flicek P; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
  • Smedley D; The Centre for Phenogenomics, Toronto, Ontario, Canada, M5T 3H7.
  • Meehan TF; The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.
  • Parkinson HE; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
  • Teboul LM; The Centre for Phenogenomics, Toronto, Ontario, Canada, M5T 3H7.
  • Wells S; The Hospital for Sick Children, Toronto, Ontario, Canada, M5G 1X8.
  • Steel KP; Canada and Mount Sinai Hospital, Toronto, Ontario, Canada, M5G 1X5.
  • Mallon AM; The Jackson Laboratory, Bar Harbor, Maine, 04609, USA.
  • Brown SDM; The Jackson Laboratory, Bar Harbor, Maine, 04609, USA.
Nat Commun ; 8(1): 886, 2017 10 12.
Article em En | MEDLINE | ID: mdl-29026089
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mapas de Interação de Proteínas / Perda Auditiva Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Mapas de Interação de Proteínas / Perda Auditiva Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article