Potency of HIV-2-specific antibodies increase in direct association with loss of memory B cells.
AIDS
; 31(17): 2431-2433, 2017 11 13.
Article
em En
| MEDLINE
| ID: mdl-29028655
ABSTRACT
Potent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infection. Thus, HIV antibody affinity maturation is linked to memory B-cell exhaustion even in reduced viremia settings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Linfócitos B
/
Anticorpos Anti-HIV
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Infecções por HIV
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HIV-2
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Anticorpos Neutralizantes
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Memória Imunológica
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article