Multi-Views Fusion CNN for Left Ventricular Volumes Estimation on Cardiac MR Images.

OBJECTIVE: Left ventricular (LV) volume estimation is a critical procedure for cardiac disease diagnosis. The objective of this paper is to address a direct LV volume prediction task. METHODS: In this paper, we propose a direct volume prediction method based on the end-to-end deep convolutional neural networks. We study the end-to-end LV volume prediction method in items of the data preprocessing, network structure, and multiview fusion strategy. The main contributions of this paper are the following aspects. First, we propose a new data preprocessing method on cardiac magnetic resonance (CMR). Second, we propose a new network structure for end-to-end LV volume estimation. Third, we explore the representational capacity of different slices and propose a fusion strategy to improve the prediction accuracy. RESULTS: The evaluation results show that the proposed method outperforms other state-of-the-art LV volume estimation methods on the open accessible benchmark datasets. The clinical indexes derived from the predicted volumes agree well with the ground truth ( ${\rm{EDV:R}}^{{\rm 2}}={\text{0.974}}$, ${\rm{RMSE\,}}= {\text{9.6}}{\rm{\,ml}}$; ${\rm{ESV:R}}^{{\rm 2}}={\text{0.976}}$, ${\rm{RMSE}}= {\text{7.1}}\,{\text{ml}}$; ${\rm{EF:R}}^{{\rm 2}} ={\text{0.828}}$, ${\rm{RMSE}}= {\text{4.71}}\% $). CONCLUSION: Experimental results prove that the proposed method may be useful for the LV volume prediction task. SIGNIFICANCE: The proposed method not only has application potential for cardiac diseases screening for large-scale CMR data, but also can be extended to other medical image research fields.