Novel activity-based probes for N-acylethanolamine acid amidase.
Chem Commun (Camb)
; 53(86): 11810-11813, 2017 Aug 22.
Article
em En
| MEDLINE
| ID: mdl-29035406
ABSTRACT
The cysteine hydrolase, N-acylethanolamine acid amidase (NAAA) is a promising target for analgesic and anti-inflammatory drugs. Here, we describe the development of two unprecedented NAAA-reactive activity-based probes as research tools for application in the discovery of new inhibitors and for the in-depth characterization of NAAA in its cellular environment.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sondas Moleculares
/
Amidoidrolases
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article