Pediatric NUT-midline carcinoma: Therapeutic success employing a sarcoma based multimodal approach.
Pediatr Hematol Oncol
; 34(4): 231-237, 2017 May.
Article
em En
| MEDLINE
| ID: mdl-29040054
ABSTRACT
A subset of poorly differentiated squamous cell carcinomas, NUT midline carcinomas (NMC) are characterized by a translocation t(15;19)(q13;p13) [ 1 ]. The prognosis is generally dismal [ 2 ] and therapeutic success has been limited to exceptional cases [ 3 ]. We present two cases of pediatric NMC from two different institutions treated according to a multimodal sarcoma approach involving surgery, chemotherapy, and focal radiotherapy. One patient has remained in complete continuous remission for over 6 years, while the other is in CR in early follow-up off therapy. Our proposed multimodal strategy apparently meets the aggressive biologic nature of NMC and should be considered for further evaluation in this context potentially in the setting of a clinical trial.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Translocação Genética
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Neoplasias da Língua
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Carcinoma de Células Escamosas
Tipo de estudo:
Prognostic_studies
Limite:
Child
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Humans
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Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article