Recombinant human islet amyloid polypeptide forms shorter fibrils and mediates ß-cell apoptosis via generation of oxidative stress.

Dubey, Richa; Minj, Pooja; Malik, Nikita; Sardesai, Devika M; Kulkarni, Shruti H; Acharya, Jhankar D; Bhavesh, Neel Sarovar; Sharma, Shilpy; Kumar, Ashutosh

Dubey, Richa; Minj, Pooja; Malik, Nikita; Sardesai, Devika M; Kulkarni, Shruti H; Acharya, Jhankar D; Bhavesh, Neel Sarovar; Sharma, Shilpy; Kumar, Ashutosh.

Afiliação

Dubey R; Department of Biosciences and Bioengineering, Indian Institute of Technology, Mumbai 400076, India.
Minj P; Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, Maharashtra 411007, India.
Malik N; Department of Biosciences and Bioengineering, Indian Institute of Technology, Mumbai 400076, India.
Sardesai DM; Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, Maharashtra 411007, India.
Kulkarni SH; Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, Maharashtra 411007, India.
Acharya JD; Department of Zoology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, Maharashtra 411007, India.
Bhavesh NS; Transcription Regulation Group, International Centre for Genetic Engineering and Biotechnology, New Delhi 110067, India.
Sharma S; Department of Biotechnology, Savitribai Phule Pune University (Formerly University of Pune), Ganeshkhind, Pune, Maharashtra 411007, India shilpy.sharma@gmail.com ashutoshk@iitb.ac.in.
Kumar A; Department of Biosciences and Bioengineering, Indian Institute of Technology, Mumbai 400076, India shilpy.sharma@gmail.com ashutoshk@iitb.ac.in.

Biochem J ; 474(23): 3915-3934, 2017 11 16.

Article em En | MEDLINE | ID: mdl-29046394

Assuntos

Apoptose/efeitos dos fármacos; Células Secretoras de Insulina/metabolismo; Polipeptídeo Amiloide das Ilhotas Pancreáticas; Estresse Oxidativo/efeitos dos fármacos; Caspase 3/biossíntese; Catalase/biossíntese; Linhagem Celular; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Células Secretoras de Insulina/patologia; Polipeptídeo Amiloide das Ilhotas Pancreáticas/química; Polipeptídeo Amiloide das Ilhotas Pancreáticas/farmacologia; Proteínas Proto-Oncogênicas c-bcl-2/biossíntese; Proteínas Recombinantes/química; Proteínas Recombinantes/farmacologia; Superóxido Dismutase-1/biossíntese; Proteína X Associada a bcl-2/biossíntese

Palavras-chave

amyloid; apoptosis; human islet amyloid polypeptide; solid-state NMR; type 2 diabetes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Apoptose / Estresse Oxidativo / Células Secretoras de Insulina / Polipeptídeo Amiloide das Ilhotas Pancreáticas Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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