CISH controls bacterial burden early after infection with Mycobacterium tuberculosis in mice.
Tuberculosis (Edinb)
; 107: 175-180, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-29050767
ABSTRACT
CISH gene has been associated with increased susceptibility to human tuberculosis. We found that cish-/- mice had higher M. tuberculosis load in spleens and lungs up to 2.5 weeks after infection but not later compared to controls. Cish mRNA levels were increased in lungs at early and late time points after M. tuberculosis infection. In relation, the titers of inos and tnf mRNA in lungs were reduced early after infection of cish-/- mice. The transfer of cish-/- and control T cells conferred rag1-/- mice similar protection to infection with M. tuberculosis. Macrophages showed increased cish mRNA levels after M. tuberculosis infection in vitro. However, mycobacterial uptake and growth in cish-/- and control macrophages was similar. Thus, we here show that CISH mediates control of M. tuberculosis in mice early after infection via regulation of innate immune mechanisms.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose Pulmonar
/
Proteínas Supressoras da Sinalização de Citocina
/
Pulmão
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Mycobacterium tuberculosis
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article