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Ets transcription factor GABP controls T cell homeostasis and immunity.
Luo, Chong T; Osmanbeyoglu, Hatice U; Do, Mytrang H; Bivona, Michael R; Toure, Ahmed; Kang, Davina; Xie, Yuchen; Leslie, Christina S; Li, Ming O.
Afiliação
  • Luo CT; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Osmanbeyoglu HU; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Do MH; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Bivona MR; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Toure A; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Kang D; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Xie Y; Immunology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Leslie CS; Louis V. Gerstner Jr. Graduate School of Biomedical Sciences, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
  • Li MO; Computational Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA.
Nat Commun ; 8(1): 1062, 2017 10 20.
Article em En | MEDLINE | ID: mdl-29051483
ABSTRACT
Peripheral T cells are maintained in the absence of vigorous stimuli, and respond to antigenic stimulation by initiating cell cycle progression and functional differentiation. Here we show that depletion of the Ets family transcription factor GA-binding protein (GABP) in T cells impairs T-cell homeostasis. In addition, GABP is critically required for antigen-stimulated T-cell responses in vitro and in vivo. Transcriptome and genome-wide GABP-binding site analyses identify GABP direct targets encoding proteins involved in cellular redox balance and DNA replication, including the Mcm replicative helicases. These findings show that GABP has a nonredundant role in the control of T-cell homeostasis and immunity.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Fator de Transcrição de Proteínas de Ligação GA Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Linfócitos T / Fator de Transcrição de Proteínas de Ligação GA Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2017 Tipo de documento: Article