The ratio of thioredoxin/Keap1 protein level is a predictor of distant metastasis in colorectal cancer.
Biomark Med
; 11(12): 1103-1111, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29053012
ABSTRACT
AIM:
Thioredoxin can reduce the cysteine group of Keap1 which could induce proteasome degradation of Nrf2, PGAM5 and Bcl-xL. Nrf2 regulates redox balance and Bcl-xL is anti-apoptotic and both are important in tumor progression.METHODS:
The protein levels of Keap1, thioredoxin, PGAM5 and Bcl-xL in the normal and tumor tissues of 64 subjects with colorectal cancer (CRC) were determined by western blot.RESULTS:
The tumor had higher Keap1 but lower PGAM5s and Bcl-xL protein expression than the normal tissue. The ratio of thioredoxin/Keap1 protein level in the normal (OR 0.12; 95% CI 0.02-0.83) or tumor tissue (OR 0.17; 95% CI 0.03-0.89) was a negative predictor for distant metastasis in CRC.CONCLUSION:
Keap1-mediated degradation of PGAM5 and Bcl-xL may be active in CRC. The ratio of thioredoxin/Keap1 protein level may be useful for suggesting distant metastasis in CRC.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tiorredoxinas
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Neoplasias Colorretais
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Proteína 1 Associada a ECH Semelhante a Kelch
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article