Tubulin Post-Translational Modifications and Microtubule Dynamics.
Int J Mol Sci
; 18(10)2017 Oct 21.
Article
em En
| MEDLINE
| ID: mdl-29065455
ABSTRACT
Microtubules are hollow tube-like polymeric structures composed of α,ß-tubulin heterodimers. They play an important role in numerous cellular processes, including intracellular transport, cell motility and segregation of the chromosomes during cell division. Moreover, microtubule doublets or triplets form a scaffold of a cilium, centriole and basal body, respectively. To perform such diverse functions microtubules have to differ in their properties. Post-translational modifications are one of the factors that affect the properties of the tubulin polymer. Here we focus on the direct and indirect effects of post-translational modifications of tubulin on microtubule dynamics.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tubulina (Proteína)
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Processamento de Proteína Pós-Traducional
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Microtúbulos
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article