Resveratrol-based cinnamic ester hybrids: synthesis, characterization, and anti-inflammatory activity.
J Enzyme Inhib Med Chem
; 32(1): 1282-1290, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29072109
ABSTRACT
Twenty-three novel resveratrol-based cinnamic ester hybrids were designed and synthesized. All the compounds were evaluated for their anti-inflammatory activity using RAW264.7 cells. Among them, compound D15 was found to be the most potent one in inhibiting NO production in LPS-stimulated RAW264.7 cells. The further study indicated that compound D15 could suppress expression of proteins iNOS, COX-2, p-p65, and p-IκB LPS-induced. Immunofluorescence further revealed compound D15 could reduce activation p65 in nuclei. All the results indicated that the anti-inflammatory activity of title compound may partly due to its inhibitory effect on the NF-κB signaling pathway.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Estilbenos
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Cinamatos
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Ésteres
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Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article