Cardiovascular homeostasis dependence on MICU2, a regulatory subunit of the mitochondrial calcium uniporter.

Bick, Alexander G; Wakimoto, Hiroko; Kamer, Kimberli J; Sancak, Yasemin; Goldberger, Olga; Axelsson, Anna; DeLaughter, Daniel M; Gorham, Joshua M; Mootha, Vamsi K; Seidman, J G; Seidman, Christine E

Bick, Alexander G; Wakimoto, Hiroko; Kamer, Kimberli J; Sancak, Yasemin; Goldberger, Olga; Axelsson, Anna; DeLaughter, Daniel M; Gorham, Joshua M; Mootha, Vamsi K; Seidman, J G; Seidman, Christine E.

Afiliação

Bick AG; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Wakimoto H; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Kamer KJ; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Sancak Y; Department of Systems Biology, Harvard Medical School, Boston, MA 02115.
Goldberger O; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Axelsson A; Department of Systems Biology, Harvard Medical School, Boston, MA 02115.
DeLaughter DM; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114.
Gorham JM; Department of Systems Biology, Harvard Medical School, Boston, MA 02115.
Mootha VK; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Seidman JG; Department of Genetics, Harvard Medical School, Boston, MA 02115.
Seidman CE; Department of Genetics, Harvard Medical School, Boston, MA 02115.

Proc Natl Acad Sci U S A ; 114(43): E9096-E9104, 2017 10 24.

Article em En | MEDLINE | ID: mdl-29073106

Assuntos

Canais de Cálcio/metabolismo; Proteínas de Ligação ao Cálcio/metabolismo; Cálcio/metabolismo; Cardiomiopatia Hipertrófica Familiar/genética; Angiotensina Amida/genética; Angiotensina II/farmacologia; Animais; Aorta Abdominal/patologia; Canais de Cálcio/genética; Proteínas de Ligação ao Cálcio/genética; Cardiomiopatia Hipertrófica Familiar/patologia; Eletrocardiografia; Regulação da Expressão Gênica; Homeostase/efeitos dos fármacos; Homeostase/fisiologia; Humanos; Camundongos Endogâmicos C57BL; Camundongos Mutantes; Mitocôndrias Hepáticas/fisiologia; Miócitos Cardíacos/patologia; Miócitos Cardíacos/fisiologia

Palavras-chave

aortic aneurysms; calcium; diastolic dysfunction; hypertension; mitochondrial calcium uniporter

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ligação ao Cálcio / Canais de Cálcio / Cálcio / Cardiomiopatia Hipertrófica Familiar Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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