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MYC-dependent downregulation of telomerase by FLT3 inhibitors is required for their therapeutic efficacy on acute myeloid leukemia.
Zhang, Xiaolu; Li, Bingnan; Yu, Jingya; Dahlström, Jenny; Tran, Anh Nhi; Björkholm, Magnus; Xu, Dawei.
Afiliação
  • Zhang X; Center for Hematology, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Li B; Center for Hematology, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Yu J; Center for Hematology, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Dahlström J; Center for Hematology, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Tran AN; Department of Clinical Genetics, Karolinska University Hospital and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Björkholm M; Center for Hematology, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden.
  • Xu D; Center for Hematology, Department of Medicine and Center for Molecular Medicine, Karolinska University Hospital Solna and Karolinska Institutet, SE-171 76, Stockholm, Sweden. Dawei.Xu@ki.se.
Ann Hematol ; 97(1): 63-72, 2018 01.
Article em En | MEDLINE | ID: mdl-29080039
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas c-myc / Telomerase / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases Limite: Adult / Aged / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Mieloide Aguda / Proteínas Proto-Oncogênicas c-myc / Telomerase / Resistencia a Medicamentos Antineoplásicos / Inibidores de Proteínas Quinases Limite: Adult / Aged / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article