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Glioblastoma and chemoresistance to alkylating agents: Involvement of apoptosis, autophagy, and unfolded protein response.
Hombach-Klonisch, Sabine; Mehrpour, Maryam; Shojaei, Shahla; Harlos, Craig; Pitz, Marshall; Hamai, Ahmed; Siemianowicz, Krzysztof; Likus, Wirginia; Wiechec, Emilia; Toyota, Brian D; Hoshyar, Reyhane; Seyfoori, Amir; Sepehri, Zahra; Ande, Sudharsana R; Khadem, Forough; Akbari, Mohsen; Gorman, Adrienne M; Samali, Afshin; Klonisch, Thomas; Ghavami, Saeid.
Afiliação
  • Hombach-Klonisch S; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  • Mehrpour M; Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, F-75993 Paris, France; Université Paris Descartes-Sorbonne Paris Cité, F-75012 Paris, France.
  • Shojaei S; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Science, Isfahan, Iran.
  • Harlos C; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.
  • Pitz M; Department of Internal Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada.
  • Hamai A; Institut Necker-Enfants Malades (INEM), INSERM U1151-CNRS UMR 8253, F-75993 Paris, France; Université Paris Descartes-Sorbonne Paris Cité, F-75012 Paris, France.
  • Siemianowicz K; Department of Biochemistry, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
  • Likus W; Department of Anatomy, School of Health Sciences in Katowice, Medical University of Silesia, Katowice, Poland.
  • Wiechec E; Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
  • Toyota BD; Division of Neurosurgery, Department of Surgery, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada.
  • Hoshyar R; Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran; Department of Clinical Biochemistry, School of Medicine, Birjand University of Medical Sciences, Birjand, Iran.
  • Seyfoori A; Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada.
  • Sepehri Z; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Internal Medicine Department, School of Medicine, Zabol University of Medical Sciences, Zabol, Iran.
  • Ande SR; Department of Internal Medicine, University of Manitoba, Winnipeg, MB, Canada.
  • Khadem F; Department of Immunology, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada.
  • Akbari M; Laboratory for Innovation in Microengineering (LiME), Department of Mechanical Engineering, University of Victoria, Victoria, BC, Canada.
  • Gorman AM; Apoptosis Research Centre, National University of Ireland, Galway, Ireland; School of Natural Sciences, National University of Ireland, Galway, Ireland.
  • Samali A; Apoptosis Research Centre, National University of Ireland, Galway, Ireland; School of Natural Sciences, National University of Ireland, Galway, Ireland.
  • Klonisch T; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Research Institute of Oncology and Hematology, CancerCare Manitoba, Winnipeg, MB, Canada. Electronic address: thomas.klonisch@umanitoba.ca.
  • Ghavami S; Department of Human Anatomy & Cell Science, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, MB, Canada; Health Policy Research Centre, Shiraz Medical University of Medical Science, Shiraz, Iran. Electronic address: saeid.ghavami@umanitoba.ca.
Pharmacol Ther ; 184: 13-41, 2018 04.
Article em En | MEDLINE | ID: mdl-29080702
Despite advances in neurosurgical techniques and radio-/chemotherapy, the treatment of brain tumors remains a challenge. This is particularly true for the most frequent and fatal adult brain tumor, glioblastoma (GB). Upon diagnosis, the average survival time of GB patients remains only approximately 15months. The alkylating drug temozolomide (TMZ) is routinely used in brain tumor patients and induces apoptosis, autophagy and unfolded protein response (UPR). Here, we review these cellular mechanisms and their contributions to TMZ chemoresistance in brain tumors, with a particular emphasis on TMZ chemoresistance in glioma stem cells and GB.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias Encefálicas / Apoptose / Glioblastoma / Resistencia a Medicamentos Antineoplásicos / Resposta a Proteínas não Dobradas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Autofagia / Neoplasias Encefálicas / Apoptose / Glioblastoma / Resistencia a Medicamentos Antineoplásicos / Resposta a Proteínas não Dobradas Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article