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Role of Diabetes Mellitus on Treatment Effects in Drug-susceptible Initial Pulmonary Tuberculosis Patients in China.
Ma, Yan; Huang, Mai Ling; Li, Tao; DU, Jian; Shu, Wei; Xie, Shi Heng; Wang, Hong Hong; Zhu, Guo Feng; Tan, Shou Yong; Fu, Yan Yong; Ma, Li Ping; Zhang, Lian Ying; Liu, Fei Ying; Hu, Dai Yu; Zhang, Yan Ling; Li, Xiang Qun; Liu, Yu Hong; Li, Liang.
Afiliação
  • Ma Y; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Huang ML; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Li T; .
  • DU J; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Shu W; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Xie SH; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Wang HH; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Zhu GF; Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
  • Tan SY; Guangzhou Chest Hospital, Guangzhou 510095, Guangdong, China.
  • Fu YY; Tianjin Centers for Disease Control and Prevention, Tianjin 300041, China.
  • Ma LP; Department of TB Control, Henan Center for Disease Control and Prevention, Zhengzhou 450016, Henan, China.
  • Zhang LY; Hebei Center for Disease Control and Prevention, Shijiazhuang 050021, Hebei, China.
  • Liu FY; Department of TB Control, Guangxi Center for Disease Control and Prevention, Nanning 530021, Guangxi, China.
  • Hu DY; Chongqing Anti-tuberculosis Institute, Chongqing 400050, China.
  • Zhang YL; Yunnan Center for Disease Control and Prevention, Kunming 650022, Yunnan, China.
  • Li XQ; Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China.
  • Liu YH; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
  • Li L; Beijing Chest Hospital, Capital Medical University, Beijing 101149, China; Beijing Tuberculosis and Thoracic Tumor Research Institute, Beijing 101149, China; Administration Office, Clinical Center on Tuberculosis Control, Chinese Center for Disease Control and Prevention, Beijing 101149, China.
Biomed Environ Sci ; 30(9): 671-675, 2017 Sep.
Article em En | MEDLINE | ID: mdl-29081342
ABSTRACT
We assessed the role of diabetes mellitus (DM) on treatment effects in drug-susceptible initial pulmonary tuberculosis (PTB) patients. A prospective study was conducted in eight provinces of China from October 2008 to December 2010. We enrolled 1,313 confirmed drug-susceptible initial PTB patients, and all subjects received the treatment regimen (2H3R3E3Z3/4H3R3) as recommended by the national guidelines. Of the 1,313 PTB patients, 157 (11.9%) had DM; these patients had more sputum smear-positive rates at the end of the second month [adjusted odds ratios (aOR) 2.829, 95% confidence intervals (CI) 1.783-4.490], and higher treatment failure (aOR 2.120, 95% CI 1.565-3.477) and death rates (aOR 1.536, 95% CI 1.011-2.628). DM was a contributing factor for culture-positive rates at the end of the second month and treatment failure and death of PTB patients, thus playing an unfavorable role in treatment effects of PTB.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Diabetes Mellitus / Antituberculosos Tipo de estudo: Guideline / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tuberculose Pulmonar / Diabetes Mellitus / Antituberculosos Tipo de estudo: Guideline / Observational_studies / Risk_factors_studies Limite: Female / Humans / Male País como assunto: Asia Idioma: En Ano de publicação: 2017 Tipo de documento: Article