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Nanobodies effectively modulate the enzymatic activity of CD38 and allow specific imaging of CD38+ tumors in mouse models in vivo.
Fumey, William; Koenigsdorf, Julia; Kunick, Valentin; Menzel, Stephan; Schütze, Kerstin; Unger, Mandy; Schriewer, Levin; Haag, Friedrich; Adam, Gerhard; Oberle, Anna; Binder, Mascha; Fliegert, Ralf; Guse, Andreas; Zhao, Yong Juan; Cheung Lee, Hon; Malavasi, Fabio; Goldbaum, Fernando; van Hegelsom, Rob; Stortelers, Catelijne; Bannas, Peter; Koch-Nolte, Friedrich.
Afiliação
  • Fumey W; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Koenigsdorf J; Department of Radiology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Kunick V; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Menzel S; Department of Radiology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Schütze K; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Unger M; Department of Radiology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Schriewer L; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Haag F; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Adam G; Department of Radiology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Oberle A; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Binder M; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Fliegert R; Department of Radiology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Guse A; Institute of Immunology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Zhao YJ; Department of Radiology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Cheung Lee H; Department of Oncology and Hematology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Malavasi F; Department of Oncology and Hematology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Goldbaum F; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • van Hegelsom R; Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
  • Stortelers C; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
  • Bannas P; School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, 518055, China.
  • Koch-Nolte F; Lab of Immunogenetics, Department of Medical Sciences, University of Torino Medical School, I-10126, Torino, Italy.
Sci Rep ; 7(1): 14289, 2017 10 30.
Article em En | MEDLINE | ID: mdl-29084989
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / ADP-Ribosil Ciclase 1 / Anticorpos de Domínio Único / Anticorpos Monoclonais / Mieloma Múltiplo / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glicoproteínas de Membrana / ADP-Ribosil Ciclase 1 / Anticorpos de Domínio Único / Anticorpos Monoclonais / Mieloma Múltiplo / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article