Combating virulence of Gram-negative bacilli by OmpA inhibition.
Sci Rep
; 7(1): 14683, 2017 10 31.
Article
em En
| MEDLINE
| ID: mdl-29089624
ABSTRACT
Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Pseudomonas aeruginosa
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Infecções por Pseudomonas
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Proteínas da Membrana Bacteriana Externa
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Aderência Bacteriana
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Infecções por Acinetobacter
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Sepse
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RNA Helicases
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Acinetobacter baumannii
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Fatores de Virulência
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Female
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Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article