Implications of failure to achieve a result from prenatal maternal serum cell-free DNA testing: a historical cohort study.
BJOG
; 125(7): 848-855, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29090507
ABSTRACT
OBJECTIVE:
To investigate the pregnancy outcomes in a cohort of women who failed to obtain a result in non-invasive prenatal testing (NIPT).DESIGN:
Historical cohort study.SETTING:
A multicentre private practice in Sydney, Australia. POPULATION Women who failed to obtain a result from NIPT (n = 131).METHODS:
The maternal characteristics, antenatal investigations and pregnancy outcomes for these women were compared with those who obtained a result at the same practice and to the general Australian obstetric population. MAIN OUTCOMEMEASURES:
Antenatal investigations pregnancy-associated plasma protein-A (PAPP-A), free ß-human chorionic gonadotrophin (ß-hCG), placental growth factor (PlGF), uterine artery pulsatility index (PI), mean arterial pressure (MAP). Pregnancyoutcomes:
chromosomal abnormality, pre-eclampsia, gestational diabetes, small-for-gestational-age (SGA), preterm delivery.RESULTS:
Only 1.1% of NIPT samples failed to return a result. This cohort was significantly older and had significantly increased weight compared with the general Australian obstetric population. Pregnancy outcomes were available for 94% of the cohort. There were significantly higher rates of chromosomal aneuploidies (6.5% versus 0.2%, P < 0.0001), pre-eclampsia (11% versus 1.5%, P < 0.0001) and gestational diabetes (23% versus 7.5%, P < 0.0001) compared with the general obstetric population. Rates of preterm delivery and SGA were elevated but did not reach significance. Antenatal investigations demonstrated decreased PAPP-A MoM (0.75 versus 1.14, P < 0.0001), decreased free ß-hCG (0.71 versus 1.01, P < 0.0001) and increased uterine artery PI (1.79 versus 1.65, P = 0.02).CONCLUSION:
Women who fail to obtain a result from NIPT are at increased risk of adverse pregnancy outcomes, in particular chromosomal aneuploidy, gestational diabetes and pre-eclampsia.FUNDING:
None received. TWEETABLE ABSTRACT Women who fail to obtain a result from cell-free DNA NIPT are at increased risk of adverse pregnancy outcomes.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Erros de Diagnóstico
/
Testes para Triagem do Soro Materno
/
Ácidos Nucleicos Livres
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Pregnancy
País como assunto:
Oceania
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article