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Enhancing inactivation rather than reducing activation of Nav1.7 channels by a clinically effective analgesic CNV1014802.
Zheng, Yue-Ming; Wang, Wan-Fu; Li, Yan-Fen; Yu, Yong; Gao, Zhao-Bing.
Afiliação
  • Zheng YM; CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Wang WF; CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Li YF; Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China.
  • Yu Y; CAS Key Laboratory of Receptor Research, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Gao ZB; Shanghai Key Laboratory of Bio-Energy Crops, School of Life Sciences, Shanghai University, Shanghai 200444, China.
Acta Pharmacol Sin ; 39(4): 587-596, 2018 Apr.
Article em En | MEDLINE | ID: mdl-29094728
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Éteres Fenílicos / Prolina / Canal de Sódio Disparado por Voltagem NAV1.7 / Bloqueadores do Canal de Sódio Disparado por Voltagem / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Éteres Fenílicos / Prolina / Canal de Sódio Disparado por Voltagem NAV1.7 / Bloqueadores do Canal de Sódio Disparado por Voltagem / Analgésicos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article