Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease.
J Cyst Fibros
; 17(2S): S40-S45, 2018 03.
Article
em En
| MEDLINE
| ID: mdl-29107600
ABSTRACT
Cystic Fibrosis (CF) lung disease is associated with dysregulation of host defence systems, which ultimately disrupts the balance between inflammation and resolution and leaves the host susceptible to repeated infection. However, the mechanisms underlying these defects are complex and continue to garner significant interest among the CF research community. This review explores emerging data on novel aspects of innate host defence with promising biomarker and therapeutic potential for CF lung disease. Improved understanding of inflammation and host defence against pathogens in patients and animal models during the progression of CF lung disease is pivotal for the discovery of new therapeutics that can limit and/or prevent damage from birth.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulador de Condutância Transmembrana em Fibrose Cística
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Fibrose Cística
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Interações Hospedeiro-Patógeno
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Imunidade Inata
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article