A High-Resolution Crystal Structure that Reveals Molecular Details of Target Recognition by the Calcium-Dependent Lipopeptide Antibiotic Laspartomycinâ
C.
Angew Chem Int Ed Engl
; 56(52): 16546-16549, 2017 12 22.
Article
em En
| MEDLINE
| ID: mdl-29108098
ABSTRACT
The calcium-dependent antibiotics (CDAs) are an important emerging class of antibiotics. The crystal structure of the CDA laspartomycinâ
C in complex with calcium and the ligand geranyl-phosphate at a resolution of 1.28â
Å is reported. This is the first crystal structure of a CDA bound to its bacterial target. The structure is also the first to be reported for an antibiotic that binds the essential bacterial phospholipid undecaprenyl phosphate (C55 -P). These structural insights are of great value in the design of antibiotics capable of exploiting this unique bacterial target.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos Cíclicos
/
Lipopeptídeos
/
Antibacterianos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article