Synthesis, receptor binding studies, optical spectroscopic and in silico structural characterization of morphiceptin analogs with cis-4-amino-L-proline residues.
J Pept Sci
; 23(12): 864-870, 2017 Dec.
Article
em En
| MEDLINE
| ID: mdl-29110363
ABSTRACT
Three novel morphiceptin analogs, in which Pro in position 2 and/or 4 was replaced by cis-4-aminoproline connected with the preceding amino acid through the primary amino group, were synthesized. The opioid receptor affinities, functional assay results, enzymatic degradation studies and experimental and in silico structural analysis of such analogs are presented. Copyright © 2017 European Peptide Society and John Wiley & Sons, Ltd.
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Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Endorfinas
/
Receptores Opioides
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article