A ratiometric electrochemical biosensor for the exosomal microRNAs detection based on bipedal DNA walkers propelled by locked nucleic acid modified toehold mediate strand displacement reaction.

Zhang, Jing; Wang, Liang-Liang; Hou, Mei-Feng; Xia, Yao-Kun; He, Wen-Hui; Yan, An; Weng, Yun-Ping; Zeng, Lu-Peng; Chen, Jing-Hua

Zhang, Jing; Wang, Liang-Liang; Hou, Mei-Feng; Xia, Yao-Kun; He, Wen-Hui; Yan, An; Weng, Yun-Ping; Zeng, Lu-Peng; Chen, Jing-Hua.

Afiliação

Zhang J; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian Province 350002, PR China.
Wang LL; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China.
Hou MF; College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, Fujian Province 350002, PR China.
Xia YK; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China.
He WH; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China.
Yan A; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China.
Weng YP; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China.
Zeng LP; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China.
Chen JH; Department of Pharmaceutical Analysis, The School of Pharmacy, Fujian Medical University, Fuzhou, Fujian Province 350108, PR China. Electronic address: cjh_huaxue@126.com.

Biosens Bioelectron ; 102: 33-40, 2018 Apr 15.

Article em En | MEDLINE | ID: mdl-29121557

Assuntos

Técnicas Biossensoriais/métodos; DNA/química; Técnicas Eletroquímicas/métodos; MicroRNAs/análise; Técnicas de Amplificação de Ácido Nucleico/métodos; Oligonucleotídeos/química; Neoplasias da Mama/sangue; Neoplasias da Mama/genética; Linhagem Celular Tumoral; DNA/genética; Feminino; Humanos; Limite de Detecção; MicroRNAs/sangue; MicroRNAs/genética; Oligonucleotídeos/genética; Sistemas Automatizados de Assistência Junto ao Leito; Reprodutibilidade dos Testes

Palavras-chave

Bipedal DNA walker; Exosomal miRNAs; Locked nucleic acid; Ratiometric electrochemical biosensor; Toehold mediate strand displacement reaction

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oligonucleotídeos / DNA / Técnicas Biossensoriais / Técnicas de Amplificação de Ácido Nucleico / MicroRNAs / Técnicas Eletroquímicas Tipo de estudo: Diagnostic_studies / Evaluation_studies / Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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