An inâ
situ Dynamic Continuum of Supramolecular Phosphoglycopeptides Enables Formation of 3D Cell Spheroids.
Angew Chem Int Ed Engl
; 56(51): 16297-16301, 2017 12 18.
Article
em En
| MEDLINE
| ID: mdl-29125896
ABSTRACT
Higher-order assemblies of proteins, with a structural and dynamic continuum, is an important concept in biology, but these insights have yet to be applied in designing biomaterials. Dynamic assemblies of supramolecular phosphoglycopeptides (sPGPs) transform a 2D cell sheet into 3D cell spheroids. A ligand-receptor interaction between a glycopeptide and a phosphopeptide produces sPGPs that form nanoparticles, which transform into nanofibrils upon partial enzymatic dephosphorylation. The assemblies form dynamically and hierarchically inâ
situ on the cell surface, and interact with the extracellular matrix molecules and effectively abolish contact inhibition of locomotion (CIL) of the cells. Integrating molecular recognition, catalysis, and assembly, these active assemblies act as a dynamic continuum to disrupt CIL, thus illustrating a new kind of biomaterial for regulating cell behavior.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glicopeptídeos
/
Esferoides Celulares
Limite:
Humans
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article