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Tissue injury of the remnant liver following radiofrequency-assisted partial hepatectomy.
Ypsilantis, Petros; Lambropoulou, Maria; Karayiannakis, Anastasios; Milicevic, Miroslav; Bulajic, Predrag; Zacharoulis, Dimitrios; Sioka, Eleni; Simopoulos, Constantinos.
Afiliação
  • Ypsilantis P; Laboratory of Experimental Surgery and Surgical Research, School of Medicine, Democritus University of Thrace, Alexandroupolis, Greece.
J BUON ; 22(5): 1172-1179, 2017.
Article em En | MEDLINE | ID: mdl-29135099
ABSTRACT

PURPOSE:

To evaluate remnant liver tissue damage in a pig model of radiofrequency (RF)-assisted liver resection employing either the sequential coagulate cut (SCC) Belgrade technique using a monopolar RF electrode or the one using the bipolar Habib-4x device.

METHODS:

Sixteen pigs underwent either a) resection of part of the left lateral and left median hepatic lobes employing the SCC (SCC group), the Habib-4X (H group) or the "crushclamp" technique (CC group) or b) sham operation (Sham group). Forty-eight hours later, tissue specimens were excised from the right lateral hepatic lobe for histopathological examination and immunohistochemical assessment of tissue injury, mitosis and inflammation.

RESULTS:

Histopathologic lesions, apoptotic activity, HSP 40 and TNFα expression were more intense, while mitotic activity was less prominent in the SCC group technique compared to H group. Comparison between CC and H groups suggested the pivotal role of partial hepatectomy (PH) per se in the changes noted in H group.

CONCLUSION:

The Habib-4X liver resection technique proved to be less injurious in the remnant liver tissue after PH compared to the SCC technique.
Assuntos
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Base de dados: MEDLINE Assunto principal: Laparoscopia / Hepatectomia / Fígado / Neoplasias Hepáticas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Laparoscopia / Hepatectomia / Fígado / Neoplasias Hepáticas Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2017 Tipo de documento: Article