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Synthesis, Spectroscopic Characterization and Antimicrobial Potential of Certain New Isatin-Indole Molecular Hybrids.
Al-Wabli, Reem I; Zakaria, Azza S; Attia, Mohamed I.
Afiliação
  • Al-Wabli RI; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. ralwabli@KSU.EDU.SA.
  • Zakaria AS; Department of Microbiology and Immunology, Faculty of Pharmacy, Alexandria University, Alexandria 21500, Egypt. azzazakaria@yahoo.com.
  • Attia MI; Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia. mattia@ksu.edu.sa.
Molecules ; 22(11)2017 Nov 15.
Article em En | MEDLINE | ID: mdl-29140257
Molecular hybridization has a wide application in medicinal chemistry to obtain new biologically active compounds. New isatin-indole molecular hybrids 5a-n have been synthesized and characterized by various spectroscopic tools. The in vitro antimicrobial potential of the prepared compounds 5a-n was assessed using diameter of the inhibition zone (DIZ) and minimum inhibitory concentration (MIC) assays against a panel of Gram-negative bacteria, Gram-positive bacteria and fungi. Most of the synthesized compounds 5a-n showed weak activities against Gram-negative bacteria while compounds 5b and 5c exhibited good activities against Gram-positive bacteria. On the other hand, compound 5j emerged as the most active compound towards Candida albicans (C. albicans), with an MIC value of 3.9 µg/mL, and compound 5g as the most active congener towards Asperagillus niger (A. niger), with an MIC value of 15.6 µg/mL. Moreover, compound 5h manifested the best anti-P. notatum effect, with an MIC value of 7.8 µg/mL, making it equipotent with compound 5g.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indóis / Anti-Infecciosos Idioma: En Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Indóis / Anti-Infecciosos Idioma: En Ano de publicação: 2017 Tipo de documento: Article