Minimotif Miner 4: a million peptide minimotifs and counting.
Nucleic Acids Res
; 46(D1): D465-D470, 2018 01 04.
Article
em En
| MEDLINE
| ID: mdl-29140456
ABSTRACT
Minimotif Miner (MnM) is a database and web system for analyzing short functional peptide motifs, termed minimotifs. We present an update to MnM growing the database from â¼300 000 to >1 000 000 minimotif consensus sequences and instances. This growth comes largely from updating data from existing databases and annotation of articles with high-throughput approaches analyzing different types of post-translational modifications. Another update is mapping human proteins and their minimotifs to know human variants from the dbSNP, build 150. Now MnM 4 can be used to generate mechanistic hypotheses about how human genetic variation affect minimotifs and outcomes. One example of the utility of the combined minimotif/SNP tool identifies a loss of function missense SNP in a ubiquitylation minimotif encoded in the excision repair cross-complementing 2 (ERCC2) nucleotide excision repair gene. This SNP reaches genome wide significance for many types of cancer and the variant identified with MnM 4 reveals a more detailed mechanistic hypothesis concerning the role of ERCC2 in cancer. Other updates to the web system include a new architecture with migration of the web system and database to Docker containers for better performance and management. Weblinksminimotifminer.org and mnm.engr.uconn.edu.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
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Software
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Processamento de Proteína Pós-Traducional
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Bases de Dados de Proteínas
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Receptores Acoplados a Proteínas G
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Proteína Grupo D do Xeroderma Pigmentoso
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article