New WS9326A Derivatives and One New Annimycin Derivative with Antimalarial Activity are Produced by Streptomyces asterosporus DSM 41452 and Its Mutant.

Zhang, Songya; Zhu, Jing; Zechel, David L; Jessen-Trefzer, Claudia; Eastman, Richard T; Paululat, Thomas; Bechthold, Andreas

Zhang, Songya; Zhu, Jing; Zechel, David L; Jessen-Trefzer, Claudia; Eastman, Richard T; Paululat, Thomas; Bechthold, Andreas.

Afiliação

Zhang S; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Stefan-Meier-Strasse 19 VF, 79104, Freiburg im Breisgau, Germany.
Zhu J; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Stefan-Meier-Strasse 19 VF, 79104, Freiburg im Breisgau, Germany.
Zechel DL; Department of Chemistry, Queen's University, 90 Bader Lane, Kingston, Ontario, K7L 3N6, Canada.
Jessen-Trefzer C; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Stefan-Meier-Strasse 19 VF, 79104, Freiburg im Breisgau, Germany.
Eastman RT; Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences/NIH, 9800 Medical Center Drive, Rockville, MD, 20850, USA.
Paululat T; Department of Chemistry and Biology, Universität Siegen, Adolf-Reichwein-Strasse 2, 57068, Siegen, Germany.
Bechthold A; Department of Pharmaceutical Biology and Biotechnology, University of Freiburg, Stefan-Meier-Strasse 19 VF, 79104, Freiburg im Breisgau, Germany.

Chembiochem ; 19(3): 272-279, 2018 02 02.

Article em En | MEDLINE | ID: mdl-29148157

Assuntos

Amidas/farmacologia; Antimaláricos/farmacologia; Ácidos Graxos Insaturados/farmacologia; Lactonas/farmacologia; Mutação; Peptídeos Cíclicos/biossíntese; Peptídeos Cíclicos/farmacologia; Streptomyces/genética; Streptomyces/metabolismo; Amidas/química; Antimaláricos/química; Antimaláricos/metabolismo; Ácidos Graxos Insaturados/biossíntese; Ácidos Graxos Insaturados/química; Lactonas/química; Conformação Molecular; Peptídeos Cíclicos/química; Streptomyces/química

Palavras-chave

P450 monooxygenase; annimycin; antimalarial activity; biosynthesis; dehydrotyrosine; mutagenesis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peptídeos Cíclicos / Streptomyces / Ácidos Graxos Insaturados / Amidas / Lactonas / Mutação / Antimaláricos Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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