Outbreaks of Neuroinvasive Astrovirus Associated with Encephalomyelitis, Weakness, and Paralysis among Weaned Pigs, Hungary.
Emerg Infect Dis
; 23(12): 1982-1993, 2017 12.
Article
em En
| MEDLINE
| ID: mdl-29148391
ABSTRACT
A large, highly prolific swine farm in Hungary had a 2-year history of neurologic disease among newly weaned (25- to 35-day-old) pigs, with clinical signs of posterior paraplegia and a high mortality rate. Affected pigs that were necropsied had encephalomyelitis and neural necrosis. Porcine astrovirus type 3 was identified by reverse transcription PCR and in situ hybridization in brain and spinal cord samples in 6 animals from this farm. Among tissues tested by quantitative RT-PCR, the highest viral loads were detected in brain stem and spinal cord. Similar porcine astrovirus type 3 was also detected in archived brain and spinal cord samples from another 2 geographically distant farms. Viral RNA was predominantly restricted to neurons, particularly in the brain stem, cerebellum (Purkinje cells), and cervical spinal cord. Astrovirus was generally undetectable in feces but present in respiratory samples, indicating a possible respiratory infection. Astrovirus could cause common, neuroinvasive epidemic disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Paraplegia
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Mamastrovirus
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Doenças dos Suínos
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Proteínas Virais
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RNA Viral
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Surtos de Doenças
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Encefalomielite
Tipo de estudo:
Prognostic_studies
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Risk_factors_studies
Limite:
Animals
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article