Chemokine CXCR-4 and cyclooxygenase-2 in the pathogenesis of pterygium
Turk J Med Sci
; 47(4): 1061-1066, 2017 08 23.
Article
em En
| MEDLINE
| ID: mdl-29152967
ABSTRACT
Background/aim:
This study aimed to investigate the expression of chemokine receptor 4 (CXCR-4) and cyclooxygenase-2 (COX-2) in the epithelium and stroma of pterygium tissue in comparison with healthy conjunctiva. Materials andmethods:
The expression of CXCR4 and COX-2 was investigated by immunohistochemistry in the epithelium and stroma of the pterygium tissue of 29 eyes and compared with healthy conjunctival tissues. The correlation between CXCR4 and COX-2 expression as well as the correlation of these markers with the area of pterygium were evaluated statistically.Results:
COX-2 staining scores were 1.75 ± 0.63 in the epithelium and 1.20 ± 0.62 in the stroma of the pterygium tissue. Mean CXCR-4 staining in the epithelium was 0.069 ± 0.37, whereas it was 5.0 ± 2.84 cells in the stroma. There was almost no staining of COX-2 and CXCR4 in the control samples. There was a strong positive correlation between the expression of CXCR-4 and COX-2 in the stroma of the pterygium.Conclusion:
CXCR-4 and COX-2 may play important roles in the pathogenesis of pterygium.
Texto completo:
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article