Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [<sup>3</sup>H]dopamine uptake at the vesicular monoamine transporter-2.

Hankosky, Emily R; Joolakanti, Shyam R; Nickell, Justin R; Janganati, Venumadhav; Dwoskin, Linda P; Crooks, Peter A

Fluoroethoxy-1,4-diphenethylpiperidine and piperazine derivatives: Potent and selective inhibitors of [³H]dopamine uptake at the vesicular monoamine transporter-2.

Hankosky, Emily R; Joolakanti, Shyam R; Nickell, Justin R; Janganati, Venumadhav; Dwoskin, Linda P; Crooks, Peter A.

Afiliação

Hankosky ER; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Joolakanti SR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Nickell JR; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Janganati V; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
Dwoskin LP; Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Crooks PA; Department of Pharmaceutical Sciences, College of Pharmacy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA. Electronic address: pacrooks@uams.edu.

Bioorg Med Chem Lett ; 27(24): 5467-5472, 2017 12 15.

Article em En | MEDLINE | ID: mdl-29153425

Assuntos

Dopamina/metabolismo; Piperazinas/química; Piperidinas/química; Proteínas Vesiculares de Transporte de Monoamina/antagonistas & inibidores; Proteínas da Membrana Plasmática de Transporte de Dopamina/química; Proteínas da Membrana Plasmática de Transporte de Dopamina/metabolismo; Canal de Potássio ERG1/metabolismo; Humanos; Cinética; Piperazinas/metabolismo; Piperidinas/metabolismo; Ligação Proteica; Serotonina/metabolismo; Proteínas da Membrana Plasmática de Transporte de Serotonina/química; Proteínas da Membrana Plasmática de Transporte de Serotonina/metabolismo; Relação Estrutura-Atividade; Proteínas Vesiculares de Transporte de Monoamina/metabolismo

Palavras-chave

Dopamine uptake; Fluoroethoxy piperidine and piperazine analogs; Lobelane; VMAT2; hERG

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Piperazinas / Piperidinas / Dopamina / Proteínas Vesiculares de Transporte de Monoamina Limite: Humans Idioma: En Ano de publicação: 2017 Tipo de documento: Article

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